Short-term memory (STM) is the ability of the mind to consciously store, maintain, and manipulate phonological (speech sound), spatial, and visual information for limited periods of time. Therefore, STM contributes to the learning of new information and aspects of speech comprehension and production. However, STM loss is observed during aging (after 55 years of age)…
White matter is parts of the brain that comprise myelinated axons, while grey matter comprises neurons bodies, axon terminals, dendrites, and synapses. Myelin that covers the white matter axons is essential for the fast transmission of electrical signals to the grey matter nerve cells, and therefore, plays a key role in learning and brain function…
Neurodegenerative diseases, such as aging-related neurodegenerative diseases and brain injuries result in severe cognitive deficits that are associated with atrophy of the hippocampus, a brain structure involved in short-term and long-term memories, and in the processing of spatial memory that controls navigation [1]. Exercise and physical activity have been shown to reduce or slow down these cognitive…
The hallmark of Alzheimer’s disease (AD) is associated with the accumulation of “senile” plaques that are composed of amyloid-beta (Aβ) protein that surround neurons in affected regions. This accumulation results in loss of neurons in the hippocampus and cerebral cortex, leading to progressive cognitive decline such as memory defects. A connection between the brain and…
The gut flora is a heterogeneous population of micro-organisms that includes bacteria, fungi, and archaea, and that plays important role in the digestion and absorbance of food. Transplantation of fecal microbiota from younger mice (Donor) to older (Recipient) enhanced their health and lifespan (longevity). During the process of aging, the function of beneficial microbes, that…
Several studies have identified a link between chronic inflammation and longevity [1]. Although inflammation, such as acute inflammation is an essential event in immune response and tissue homeostasis, chronic inflammation has been associated with chronic diseases, including diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer. These diseases are the main causes of bad quality of life,…
