The Gut Flora and Long Lifespan

The Gut Flora and Long Lifespan

The gut flora is a heterogeneous population of micro-organisms that includes bacteria, fungi, and archaea, and that plays important role in the digestion and absorbance of food. Transplantation of fecal microbiota from younger mice (Donor) to older (Recipient) enhanced their health and lifespan (longevity). During the process of aging, the function of beneficial microbes, that…

Epigenetic Diet and Longer Lifespan

Epigenetic Diet and Longer Lifespan

Epigenetic mechanisms, including DNA methylation, histone modification, and RNA interference, have been shown to play crucial roles in regulating the expression of genes that are involved in age-related diseases and longevity [1]. These mechanisms are mediated by modifying histone enzymes and noncoding RNAs. However, several environmental and dietary factors can lead to their imbalance, leading…

Chronic inflammation and longevity

Chronic inflammation and longevity

Several studies have identified a link between chronic inflammation and longevity [1]. Although inflammation, such as acute inflammation is an essential event in immune response and tissue homeostasis, chronic inflammation has been associated with chronic diseases, including diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer. These diseases are the main causes of bad quality of life,…