The gut flora is a heterogeneous population of micro-organisms that includes bacteria, fungi, and archaea, and that plays important role in the digestion and absorbance of food. Transplantation of fecal microbiota from younger mice (Donor) to older (Recipient) enhanced their health and lifespan (longevity). During the process of aging, the function of beneficial microbes, that…
Microcirculation is a network of blood vessels that provide tissues and organs with essential nutrients and oxygen for their maintenance, activities, and survival, while also cleansing the body’s waste products [1]. Therefore, a better microcirculation is key for longer and healthier life, and its impairment can lead to premature deaths [2][3]. Why Do Nonagenarians and…
Epigenetic mechanisms, including DNA methylation, histone modification, and RNA interference, have been shown to play crucial roles in regulating the expression of genes that are involved in age-related diseases and longevity [1]. These mechanisms are mediated by modifying histone enzymes and noncoding RNAs. However, several environmental and dietary factors can lead to their imbalance, leading…
